Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
Glp1 is shown to methylate histone H1 in a variant specific manner and facilitates interaction with HP1 (PMID: 20334638). It is shown to be a part of a large multimeric complex comprising of Suv39h1, G9a and SETDB1. Glp1 and G9a often work in association and hence specifically mediate H3K9 dimethylation and H3K27 methylation (PMID: 20129054, PMID: 19531572).
| UniprotKB Accession | Q9H9B1 | |
|---|---|---|
| Alternative Name(s) | ||
| Writer for PTM/s | H3K9me2, H3K27me1, H1K25me1, H1K186me1 | |
| EC number | ||
| No. of coding genes | Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 is coded by following 1 non-allelic gene/s | |
| Gene name | euchromatic histone-lysine N-methyltransferase 1 | |
| Gene symbol | EHMT1 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | Eu-HMTase1, FLJ12879, KIAA1876, bA188C12.1, KMT1D | |
| GeneID | 79813 | |
| Chromosomal location | 9 | |
| HGNC | 24650 | |
| Unigene | Hs.495511 | |
| MIM | 607001 | |
| RefSeq mRNA | NM_001145527.1 | NM_024757.4 |
| RefSeq Protein | NP_001138999.1 | NP_079033.4 |
| Disease associations | Neurological disorder: Kleefstra syndrome (KS); PMID: 21538692 | |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3