Histone-lysine N-methyltransferase SUV39H2
SUV39H2 shows specificity towards H3 lysine 9 position that causes transcriptional repression (PMID: 15107829).It methylates H3K9 at the pericentric satellite repeats that further undergoes DNA methylation and heterochromatinization in order to silence these repeats (PMID: 12867029).
| UniprotKB Accession | Q9H5I1 |
|---|---|
| Alternative Name(s) | Histone H3-K9 methyltransferase 2 (H3-K9-HMTase 2), Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2 (Su(var)3-9 homolog 2) |
| Writer for PTM/s | H3K9me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase SUV39H2 is coded by following 1 non-allelic gene/s |
| Gene name | suppressor of variegation 3-9 homolog 2 (Drosophila) |
| Gene symbol | SUV39H2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | FLJ23414, KMT1B |
| GeneID | 79723 |
| Chromosomal location | 10p13 |
| HGNC | 17287 |
| Unigene | Hs.554883 |
| MIM | 606503 |
| RefSeq mRNA | NM_024670.3 |
| RefSeq Protein | NP_078946.1 |
| Disease associations | Developmental defect: Spermatogenesis affected; PMID: 16549060 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3