Histone-lysine N-methyltransferase MLL4
MLL4 along with MLL3 acts as a coactivator of the tumour suppressor p53 and trimethylation of H3K4 (PMID: 20236313, PMID: 17500065).
| UniprotKB Accession | Q9UMN6 |
|---|---|
| Alternative Name(s) | Lysine N-methyltransferase 2D (KMT2D), Myeloid/lymphoid or mixed-lineage leukemia protein 4, Trithorax homolog 2, WW domain-binding protein 7 (WBP-7) |
| Writer for PTM/s | H3K4me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase MLL4 is coded by following 1 non-allelic gene/s |
| Gene name | |
| Gene symbol | Unknown |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | |
| GeneID | 9757 |
| Chromosomal location | |
| HGNC | |
| Unigene | Notice: Undefined offset: 1 in /var/home/coee/public_html/histome/enzyme_sp.php on line 223|
| MIM | 606834 |
| RefSeq mRNA | NM_014727.1 |
| RefSeq Protein | NP_055542.1 |
| Disease associations | Cancer: Hepatocellular carcinoma; PMID: 18320596 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3