Histone-lysine N-methyltransferase SETMAR
SETMAR aroused from the fusion of a H3 methylase with a mariner family transposase and methylates histone H3 at lysine 36. It is reported to mediate Non Homologous End Joining (NHEJ) repair in case of DNA damage. It forms an open chromatin conformation and is thought to be responsible for integration of exogenous DNA (PMID: 16332963). SETMAR catalyses H3K36 dimethylation at the site of DNA double strand breaks which help in recruitment of early DNA repair components promoting enhanced DNA repair via NHEJ (PMID: 21187428). It is also shown to be involved in replication stress response whereby it promotes start of stalled replication forks (PMID: 20457750).
| UniprotKB Accession | Q53H47 |
|---|---|
| Alternative Name(s) | SET domain and mariner transposase fusion gene-containing protein (HsMar1, Metnase) |
| Writer for PTM/s | H3K36me2 |
| EC number | 2.1.1.43, 3.1.-.- |
| No. of coding genes | Histone-lysine N-methyltransferase SETMAR is coded by following 1 non-allelic gene/s |
| Gene name | SET domain and mariner transposase fusion gene |
| Gene symbol | SETMAR |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | metnase |
| GeneID | 6419 |
| Chromosomal location | 3p26.2 |
| HGNC | 10762 |
| Unigene | Hs.475300 |
| MIM | 609834 |
| RefSeq mRNA | NM_006515.3 |
| RefSeq Protein | NP_006506.3 |
| Disease associations | No disease associations known for Histone-lysine N-methyltransferase SETMAR |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3