Histone-lysine N-methyltransferase SETD1A
It belongs to the MLL family of proteins. SETD1A mediates H3K4 methylation at the transcriptional start site (PMID: 17998332).
| UniprotKB Accession | O15047 |
|---|---|
| Alternative Name(s) | Lysine N-methyltransferase 2F, SET domain-containing protein 1A (hSET1A), Set1/Ash2 histone methyltransferase complex subunit SET1 |
| Writer for PTM/s | H3K4me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase SETD1A is coded by following 1 non-allelic gene/s |
| Gene name | SET domain containing 1A |
| Gene symbol | SETD1A |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA0339, Set1, KMT2F |
| GeneID | 9739 |
| Chromosomal location | 16p11.2 |
| HGNC | 29010 |
| Unigene | Hs.297483 |
| MIM | 611052 |
| RefSeq mRNA | NM_014712.1 |
| RefSeq Protein | NP_055527.1 |
| Disease associations | Cancer: Multiple; PMID: 19426701 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3