Histone-lysine N-methyltransferase SUV420H1
SUV420H1 catalyses methylation of H4 at Lysine 20 position. This modification is reported to recruit Heterochromatin protein HP1 to its site and mediate heterochromatinization (PMID: 20164836). It also contributes to the fetal globin gene silencing (PMID: 20495075). SUV420H1 is involved in the glucocorticoid receptor target gene transcription in a hormone-dependent manner (PMID: 19074285). Some studies report that it also catalyses the dimethylation of H4 lysine 20 residues using PR-Set7 mediated monomethylated H4K20 as substrates. This dimethylation of H4K20 is essential for proper DNA damage response (PMID: 18296440).
| UniprotKB Accession | Q4FZB7 | |
|---|---|---|
| Alternative Name(s) | Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1 (Su(var)4-20 homolog 1, Suv4-20h1) | |
| Writer for PTM/s | H4K20me2, H4K20me3 | |
| EC number | 2.1.1.43 | |
| No. of coding genes | Histone-lysine N-methyltransferase SUV420H1 is coded by following 1 non-allelic gene/s | |
| Gene name | suppressor of variegation 4-20 homolog 1 (Drosophila) | |
| Gene symbol | SUV420H1 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | CGI-85, KMT5B | |
| GeneID | 51111 | |
| Chromosomal location | 11q13.2 | |
| HGNC | 24283 | |
| Unigene | Hs.632120 | |
| MIM | 610881 | |
| RefSeq mRNA | NM_016028.4 | NM_017635.3 |
| RefSeq Protein | NP_057112.3 | NP_060105.3 |
| Disease associations | No disease associations known for Histone-lysine N-methyltransferase SUV420H1 | |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3