Probable histone-lysine N-methyltransferase ASH1L

Ash1 is a SET domain containing protein that exclusively mono- and di- methylates histone H3 Lysine 36 (PMID: 17544230). Ash1 is found to be associated with transcriptionally active genes (PMID: 17923682).

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Probable histone-lysine N-methyltransferase ASH1L infosheet
UniprotKB AccessionQ9NR48
Alternative Name(s)ASH1-like protein (huASH1), Absent small and homeotic disks protein 1 homolog, Lysine N-methyltransferase 2H
Writer for PTM/s H3K36me1, H3K36me2
EC number 2.1.1.43
No. of coding genesProbable histone-lysine N-methyltransferase ASH1L is coded by following 1 non-allelic gene/s
Gene nameash1 (absent, small, or homeotic)-like (Drosophila)
Gene symbolASH1L
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliaseshuASH1, ASH1, ASH1L1, KMT2H
GeneID55870
Chromosomal location1q22
HGNC19088
UnigeneHs.491060
MIM607999
RefSeq mRNANM_018489.2
RefSeq ProteinNP_060959.2
Disease associationsNo disease associations known for Probable histone-lysine N-methyltransferase ASH1L

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3