Histone-lysine N-methyltransferase MLL3
It belongs to the MLL family of proteins. MLL3 gene is frequently either mutated or deleted in primary breast cancer, colon cancer and myeloid leukaemia. Also required for H3K4 trimethylation (PMID: 21116761, PMID: 20126641, PMID: 11891048, PMID: 17500065).
| UniprotKB Accession | Q8NEZ4 |
|---|---|
| Alternative Name(s) | Homologous to ALR protein, Lysine N-methyltransferase 2C (KMT2C), Myeloid/lymphoid or mixed-lineage leukemia protein 3 |
| Writer for PTM/s | H3K4me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase MLL3 is coded by following 1 non-allelic gene/s |
| Gene name | myeloid/lymphoid or mixed-lineage leukemia 3 |
| Gene symbol | MLL3 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA1506, HALR, KMT2C |
| GeneID | 58508 |
| Chromosomal location | 7q36 |
| HGNC | 13726 |
| Unigene | Hs.647120 |
| MIM | 606833 |
| RefSeq mRNA | NM_170606.2 |
| RefSeq Protein | NP_733751.2 |
| Disease associations | Cancer: Hematological neoplasia; PMID: 11718452 Neurological disorder: Holoprosensephaly; PMID: 11718452 Cancer: Myeloid leukemia; PMID: 11891048 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3