Histone-lysine N-methyltransferase MLL5
MLL5 is a SET domain containing methyltransferase and is ubiquitously expressed. Overexpression of MLL5 is shown to inhibit cell cycle progression, suggesting its role as a tumour suppressor. MLL5 is also reported to form complexes and influence chromatin remodelling (PMID: 14718661). Inhibition of MLL5 is responsible for the G1 and G2/M phase arrest of the cell cycle, hence it acts as a cell cycle regulator (PMID: 18573682).
| UniprotKB Accession | Q8IZD2 | |
|---|---|---|
| Alternative Name(s) | Lysine N-methyltransferase 2E (KMT2E), Myeloid/lymphoid or mixed-lineage leukemia protein 5 | |
| Writer for PTM/s | ||
| EC number | 2.1.1.43 | |
| No. of coding genes | Histone-lysine N-methyltransferase MLL5 is coded by following 1 non-allelic gene/s | |
| Gene name | myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) | |
| Gene symbol | MLL5 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | HDCMC04P, KMT2E | |
| GeneID | 55904 | |
| Chromosomal location | 7q22.1 | |
| HGNC | 18541 | |
| Unigene | Hs.592262 | |
| MIM | 608444 | |
| RefSeq mRNA | NM_018682.3 | NM_182931.2 |
| RefSeq Protein | NP_061152.3 | NP_891847.1 |
| Disease associations | No disease associations known for Histone-lysine N-methyltransferase MLL5 | |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3