Histone-lysine N-methyltransferase SETD1B
SETD1B is a SET domain containing methyltransferase that specifically methylates histone H3 at lysine 4 position. It functions in a non redundant manner with SETD1A (PMID: 17355966).
| UniprotKB Accession | Q9UPS6 |
|---|---|
| Alternative Name(s) | Lysine N-methyltransferase 2G, SET domain-containing protein 1B (hSET1B) |
| Writer for PTM/s | H3K4me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase SETD1B is coded by following 1 non-allelic gene/s |
| Gene name | SET domain containing 1B |
| Gene symbol | SETD1B |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA1076, Set1B, KMT2G |
| GeneID | 23067 |
| Chromosomal location | 12q24.31 |
| HGNC | 29187 |
| Unigene | Hs.507122 |
| MIM | 611055 |
| RefSeq mRNA | NM_015048.1 |
| RefSeq Protein | NP_055863.1 |
| Disease associations | No disease associations known for Histone-lysine N-methyltransferase SETD1B |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3