SET and MYND domain-containing protein 3
SMYD2 catalyses trimethylation of histone H3 at lysine 4 position. It has a SET domain and an MYND domain that forms a unique domain architecture. SMYD3 is overexpressed in colorectal cancers and helps in carcinogenesis (PMID: 15235609). SMYD3 knockdown causes cell cycle arrest and induction of apoptosis. This suggests its importance in cancer therapeutics (PMID: 20957523). Also reported to trans-activate the telomerase reverse transcriptase (hTERT) gene (PMID: 17363582).
| UniprotKB Accession | Q9H7B4 |
|---|---|
| Alternative Name(s) | Zinc finger MYND domain-containing protein 1 |
| Writer for PTM/s | H3K4me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | SET and MYND domain-containing protein 3 is coded by following 1 non-allelic gene/s |
| Gene name | SET and MYND domain containing 3 |
| Gene symbol | SMYD3 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | ZNFN3A1, ZMYND1 |
| Aliases | KMT3E |
| GeneID | 64754 |
| Chromosomal location | 1q44 |
| HGNC | 15513 |
| Unigene | Hs.567571 |
| MIM | 608783 |
| RefSeq mRNA | NM_022743.2 |
| RefSeq Protein | NP_073580.1 |
| Disease associations | Cancer: Colorectal cancer; PMID: 15235609 Cancer: Hepatocellular carcinoma; PMID: 15235609 Cancer: Breast cancer; PMID: 16441421 Cancer: Cervical cancer; PMID: 18452649 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3