Histone-lysine N-methyltransferase SETD8
PR-SET7 contains a SET domain and whether it is a monomethylase or a dimethylase is debatable. Some reports state that it is exclusively a monomethylase (PMID: 15933069) whereas others show a switch from mono to dimethylatation at lysine 20 position of histone H4 upon PR-SET7 activation (PMID: 15200950). PR-SET7 mediated H4K20 methylation status (mono- or di-) contributes to chromosome behaviour during mitosis and is required for proper cytokinesis (PMID: 15200950). PR-SET7/SET8 is necessary for progression of cell cycle to S phase (PMID: 18166648). H4K20 monomethylation helps in loading of the pre-RC proteins on the origin of replication and plays an important role during initiation of DNA replication (PMID: 20953199). PR-SET7 is shown to be undetectable during S phase and its interaction-mediated degradation via PCNA in context of DNA damage is required for maintaining the integrity of the genome (PMID: 21035370).
| UniprotKB Accession | Q9NQR1 |
|---|---|
| Alternative Name(s) | |
| Writer for PTM/s | H4K20me1, H4K20me2 |
| EC number | |
| No. of coding genes | Histone-lysine N-methyltransferase SETD8 is coded by following 1 non-allelic gene/s |
| Gene name | SET domain containing (lysine methyltransferase) 8 |
| Gene symbol | SETD8 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | SET8, SET07, PR-Set7, KMT5A |
| GeneID | 387893 |
| Chromosomal location | 12q24.31 |
| HGNC | 29489 |
| Unigene | Hs.443735 |
| MIM | 607240 |
| RefSeq mRNA | NM_020382.3 |
| RefSeq Protein | NP_065115.3 |
| Disease associations | No disease associations known for Histone-lysine N-methyltransferase SETD8 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3