Histone-lysine N-methyltransferase SETDB2
CLLD8 contains the SET domain and methylates histone H3 at Lysine 9 position specifically at the interspersed repetitive elements and centromere-associated repeats which further recruits HP1 at the centromeric position. It is important for proper chromosomal segregation (PMID: 20404330).
| UniprotKB Accession | Q96T68 |
|---|---|
| Alternative Name(s) | Chronic lymphocytic leukemia deletion region gene 8 protein, Lysine N-methyltransferase 1F, SET domain bifurcated 2 |
| Writer for PTM/s | H3K9me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase SETDB2 is coded by following 1 non-allelic gene/s |
| Gene name | SET domain, bifurcated 2 |
| Gene symbol | SETDB2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | C13orf4 |
| Aliases | CLLD8, CLLL8, KMT1F |
| GeneID | 83852 |
| Chromosomal location | 13q14 |
| HGNC | 20263 |
| Unigene | Hs.631789 |
| MIM | 607865 |
| RefSeq mRNA | NM_031915.2 |
| RefSeq Protein | NP_114121.2 |
| Disease associations | Cancer: Chronic lymphocytic leukemia (CLL); PMID: 21151023 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3