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H3K36 methylation restricts the Polycomb repressive complex 2 (PRC2) mediated spread of H3K27 methylation (PMID: 21239496). H3K36 dimethylation is observed at the site of DNA double strand breaks and helps in the Non homologous end joining (NHEJ) repair mechanism (PMID: 21187428).

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H3K36me2 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, N-lysine methyltransferase SMYD2, Probable histone-lysine N-methyltransferase ASH1L
Eraser/s Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 8
Disease associations
Cancer: Leukemia; PMID: 21310926
Cancer: Acute myeloid leukaemia; PMID: 16861263

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3