Lysine-specific demethylase 2A
KDM2A belongs to JHDM1 family of demethylases that contains a JmJC domain. It specifically demethylates H3K36 and is conserved from yeast to humans (PMID: 16362057). KDM2A is found associated with heterochromatic regions of the genome and interacts with the Heterochromatin protein (HP1). It also localises at the centromere and facilitates the silencing of non-coding RNAs that is essential for binding of HP1 to centromere. KDM2A is reported to be downregulated in prostate cancers and is supposed to be involved in the development of carcinomas (PMID: 19001877). It regulates the expression of ribosomal RNA genes via demethylation of H3K36me2 at the promoter under starvation (PMID: 20379134). CpG islands are shown to directly recruit KDM2A to these unmethylated sites so as to differentiate CpG island containing region of chromatin from rest of the genome (PMID: 20417597). NF-kB induces the expression of KDM2A; and KDM2A in turn downregulates NF-kB expression establishing a negative feedback loop in the NF-kB signalling pathway (PMID: 20080798).
| UniprotKB Accession | Q9Y2K7 |
|---|---|
| Alternative Name(s) | CXXC-type zinc finger protein 8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, F-box/LRR-repeat protein 11, JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A |
| Eraser for PTM/s | H3K36me2 |
| EC number | 1.14.11.27 |
| No. of coding genes | Lysine-specific demethylase 2A is coded by following 1 non-allelic gene/s |
| Gene name | lysine (K)-specific demethylase 2A |
| Gene symbol | KDM2A |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | FBXL11 |
| Aliases | KIAA1004, FBL11, LILINA, DKFZP434M1735, FBL7, FLJ00115, CXXC8, JHDM1A |
| GeneID | 22992 |
| Chromosomal location | 11q13.1 |
| HGNC | 13606 |
| Unigene | Hs.124147 |
| MIM | 605657 |
| RefSeq mRNA | NM_012308.2 |
| RefSeq Protein | NP_036440.1 |
| Disease associations | Cancer: Prostate cancer; PMID: 19001877 |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B