Lysine-specific histone demethylase 1B
LSD2 belongs to the Lysine-specific demethylase (LSD) category of demethylase. It recognises the dimethylated H3K9 mark and carries out its demethylation. LSD2 is important to maintain a transcriptionally active state of the chromatin (PMID: 20670891). Demethylation of H3K9 at the NF-kB target gene promoters helps in increased binding of NF-kB and further activation of several inflammatory genes (PMID: 20832726).
| UniprotKB Accession | Q8NB78 |
|---|---|
| Alternative Name(s) | Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2 |
| Eraser for PTM/s | H3K9me2 |
| EC number | 1.-.-.- |
| No. of coding genes | Lysine-specific histone demethylase 1B is coded by following 1 non-allelic gene/s |
| Gene name | lysine (K)-specific demethylase 1B |
| Gene symbol | KDM1B |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | C6orf193, AOF1 |
| Aliases | FLJ34109, FLJ33898, dJ298J15.2, bA204B7.3, FLJ43328, LSD2 |
| GeneID | 221656 |
| Chromosomal location | 6p22.3 |
| HGNC | 21577 |
| Unigene | Hs.709336 |
| MIM | 613081 |
| RefSeq mRNA | NM_153042.3 |
| RefSeq Protein | NP_694587.3 |
| Disease associations | No disease associations known for Lysine-specific histone demethylase 1B |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B