Lysine-specific demethylase 5D
JARID1D belongs to JARID1 family of demethylase. It is a male specific antigen and mediates the demethylation of H3K4me3 and H3K4me2 (PMID: 7667640, PMID: 17320160). It is shown to co-localise with a meiosis regulatory protein MSH5 and supposed to be involved in the condensation of DNA during early meiosis (PMID: 18459961).
| UniprotKB Accession | Q9BY66 |
|---|---|
| Alternative Name(s) | Histocompatibility Y antigen (H-Y), Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY |
| Eraser for PTM/s | H3K4me3, H3K4me2 |
| EC number | 1.14.11.- |
| No. of coding genes | Lysine-specific demethylase 5D is coded by following 1 non-allelic gene/s |
| Gene name | lysine (K)-specific demethylase 5D |
| Gene symbol | KDM5D |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | HYA, HY, SMCY, JARID1D |
| Aliases | KIAA0234 |
| GeneID | 8284 |
| Chromosomal location | Yq11 |
| HGNC | 11115 |
| Unigene | Hs.80358 |
| MIM | 426000 |
| RefSeq mRNA | NM_004653.4 |
| RefSeq Protein | NP_004644.2 |
| Disease associations | No disease associations known for Lysine-specific demethylase 5D |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B