Lysine-specific demethylase 4D
It belongs to the JMJD2 family of histone demethylases and is the only member in the family which has neither a PHD nor a TUDOR domain. It catalyses the demethylation of H3K9me3. It is the only JMJD2 member to catalyse H3K4me2 methylation to a monomethylated state (PMID: 16603238). JMJD2D also catalyses the demethylation of histone H1.4 variant at lysine 25 position (reported as H1K26) in a variant specific manner (PMID: 20334638).
| UniprotKB Accession | Q6B0I6 |
|---|---|
| Alternative Name(s) | JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2D |
| Eraser for PTM/s | H3K9me3, H3K9me2, H1K25me1 |
| EC number | 1.14.11.- |
| No. of coding genes | Lysine-specific demethylase 4D is coded by following 1 non-allelic gene/s |
| Gene name | lysine (K)-specific demethylase 4D |
| Gene symbol | KDM4D |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | JMJD2D |
| Aliases | FLJ10251 |
| GeneID | 55693 |
| Chromosomal location | 11q21 |
| HGNC | 25498 |
| Unigene | Hs.503598 |
| MIM | 609766 |
| RefSeq mRNA | NM_018039.2 |
| RefSeq Protein | NP_060509.2 |
| Disease associations | No disease associations known for Lysine-specific demethylase 4D |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B