Lysine-specific demethylase 8
KDM8 belongs to the JmJC domain containing protein family but exclusively lacks the PHD/Tudor domain for binding to DNA/Chromatin. It demethylates H3K36me2 and is reported to be overexpressed in breast cancers. Since it controls the transcription of cyclin A1, it is supposed to be a cell cycle regulator (PMID: 20457893). JMJD5 is also involved in the circadian systems in humans (PMID: 21115819).
| UniprotKB Accession | Q8N371 | |
|---|---|---|
| Alternative Name(s) | JmjC domain-containing protein 5, Jumonji domain-containing protein 5 | |
| Eraser for PTM/s | H3K36me2 | |
| EC number | 1.14.11.27 | |
| No. of coding genes | Lysine-specific demethylase 8 is coded by following 1 non-allelic gene/s | |
| Gene name | jumonji domain containing 5 | |
| Gene symbol | JMJD5 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | FLJ13798 | |
| GeneID | 79831 | |
| Chromosomal location | 16p12.1 | |
| HGNC | 25840 | |
| Unigene | Hs.145717 | |
| MIM | 611917 | |
| RefSeq mRNA | NM_001145348.1 | NM_024773.2 |
| RefSeq Protein | NP_001138820.1 | NP_079049.2 |
| Disease associations | Cancer: Breast cancer; PMID: 20457893 | |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B