NAD-dependent deacetylase sirtuin-6

SIRT6 belongs to NAD+ dependent Class III of histone deacetylases. It plays a crucial role in the maintenance of telomeres and is involved in Werner syndrome (PMID: 18337721). SIRT6 is reported to deacetylate the promoters of NF-kB target genes thereby being involved in premature and normal aging (PMID: 19135889). Loss of SIRT6 has been shown to cause premature lethality and aging-related degeneration. SIRT6 is also supposed to be involved in normal DNA repair (PMID: 16439206). It is also reported to mediate the deacetylation of H3K56 at telomeric region in a cell cycle dependent manner (PMID: 19625767).

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NAD-dependent deacetylase sirtuin-6 infosheet
UniprotKB AccessionQ8N6T7
Alternative Name(s)SIR2-like protein 6
Eraser for PTM/s H3K9ac, H3K56ac
EC number 3.5.1.-
No. of coding genesNAD-dependent deacetylase sirtuin-6 is coded by following 1 non-allelic gene/s
Gene namesirtuin 6
Gene symbolSIRT6
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location19p13.3
RefSeq mRNANM_016539.2NM_001193285.1
RefSeq ProteinNP_057623.2NP_001180214.1
Disease associations
Metabolic disorder: Fatty liver disease; PMID: 20816089

Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6