Serine/threonine-protein kinase 12
Aurora B is classified under Ser/Thr protein kinase family. It mediates the H3 Serine 10 phosphorylation during mitosis. Its overexpression causes increased mitotic phosphorylation which may lead to aneuploidy formation and progression of colorectal, prostate and liver cancers (PMID: 12234980, PMID: 16267859, PMID: 17094487). Aurora B is also implicated in the regulation of cohesins in mitotic chromosomes (PMID: 17084365). Another target for Aurora B kinase activity is histone CENP-A. This phosphorylation is important for the completion of cytokinesis (PMID: 11756469). Aurora B, along with other factors like survivin, INCENP and borealin, forms a chromosomal passenger complex (CPC) that is essential for the proper alignment of the chromosomes, attachment of spindle to kinetochores, cytokinesis and constitution of a spindle assembly checkpoint (PMID: 20372054). Recently SUMOylation of Aurora B at Lysine 207 site is shown to be important for the proper functioning of CPC and successful completion of mitotic phase (PMID: 20663916). Aurora B also phosphorylates H3S28 at the start of prophase and this modification is required for proper chromosomal condensation (11856369).
| UniprotKB Accession | Q96GD4 |
|---|---|
| Alternative Name(s) | Aurora kinase B, Aurora- and IPL1-like midbody-associated protein 1 (AIM-1), Aurora/IPL1-related kinase 2 (ARK-2, Aurora-related kinase 2), STK-1, Serine/threonine-protein kinase aurora-B |
| Writer for PTM/s | H3S10ph, H3S6ph, H3S28ph |
| EC number | 2.7.11.1 |
| No. of coding genes | Serine/threonine-protein kinase 12 is coded by following 1 non-allelic gene/s |
| Gene name | aurora kinase B |
| Gene symbol | AURKB |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | STK12 |
| Aliases | Aik2, IPL1, AurB, AIM-1, ARK2, STK5 |
| GeneID | 9212 |
| Chromosomal location | 17p13.1 |
| HGNC | 11390 |
| Unigene | Hs.442658 |
| MIM | 604970 |
| RefSeq mRNA | NM_004217.2 |
| RefSeq Protein | NP_004208.2 |
| Disease associations | Cancer: Prostate cancer; PMID: 16267859 Cancer: Colorectal cancer; PMID: 12234980 Cancer: Oral squamous cell carcinoma (OSCC); PMID: 17235564 |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2