Lysine-specific demethylase 5B
PLU-1/JARID1B belongs to the JARID1 family of demethylases that catalyse the demethylation of H3K4me3. This activity is responsible for removal of activation mark and repression of tumour suppressor genes which leads to proliferation of breast cancers (PMID: 17363312). It is also involved in cell cycle progression form G2 to M phase and E2F1,E2F2 are shown to be downstream targets in PLU-1 pathway (PMID: 17709396, PMID: 20226085). Expression levels of PLU-1 is reported to be significantly altered during melanoma development and in prostate cancers (PMID: 17973255, PMID: 18048344). PLU-1 also regulates the androgen receptor mediated transcriptional activation (PMID: 18048344). Using JARID1B as a biomarker, a subpopulation of melanoma cells have been identified that have a doubling time of more than 4 weeks and contributes to the maintenance of tumours. It has been proposed that dynamic expression of JARID1B does not follow the conventional cancer stem cell model (PMID: 20478252).
| UniprotKB Accession | Q9UGL1 |
|---|---|
| Alternative Name(s) | Cancer/testis antigen 31 (CT31), Histone demethylase JARID1B, Jumonji/ARID domain-containing protein 1B, PLU-1, Retinoblastoma-binding protein 2 homolog 1 (RBP2-H1) |
| Eraser for PTM/s | H3K4me3 |
| EC number | 1.14.11.- |
| No. of coding genes | Lysine-specific demethylase 5B is coded by following 1 non-allelic gene/s |
| Gene name | lysine (K)-specific demethylase 5B |
| Gene symbol | KDM5B |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | JARID1B |
| Aliases | RBBP2H1A, PLU-1, CT31 |
| GeneID | 10765 |
| Chromosomal location | 1q32.1 |
| HGNC | 18039 |
| Unigene | Hs.443650 |
| MIM | 605393 |
| RefSeq mRNA | NM_006618.3 |
| RefSeq Protein | NP_006609.3 |
| Disease associations | Cancer: Breast cancer; PMID: 17363312 Cancer: Prostrate cancer; PMID: 18048344 Cancer: Testis cancer; PMID: 12237901 |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B