Lysine-specific demethylase 6B
JMJD3 belongs to the UTX family and contains a JmJC domain. It catalyses the demethylation of majorly trimethylated H3K27 and to lower extent, dimethylated H3K27 (PMID: 17923864). NF-kB is involved in the regulation of JMJD3 as it is required for JMJD3 activation. Its activity is required for regulation of Hox genes (PMID: 17825402). It also plays an essential role in regulating cellular differentiation (PMID: 18628393). Jmjd3 controls the process of cellular senescence by regulating INK4a/ARF tumour suppressor locus (PMID: 19451218). Expression level of JMJD3 has been reported to rise in during prostate cancers and more so in metastatic prostate cancers (PMID: 17923864).
| UniprotKB Accession | O15054 |
|---|---|
| Alternative Name(s) | JmjC domain-containing protein 3, Jumonji domain-containing protein 3, Lysine demethylase 6B |
| Eraser for PTM/s | H3K27me3, H3K27me2 |
| EC number | 1.14.11.- |
| No. of coding genes | Lysine-specific demethylase 6B is coded by following 1 non-allelic gene/s |
| Gene name | lysine (K)-specific demethylase 6B |
| Gene symbol | KDM6B |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | JMJD3 |
| Aliases | KIAA0346 |
| GeneID | 23135 |
| Chromosomal location | 17p13.1 |
| HGNC | 29012 |
| Unigene | Hs.223678 |
| MIM | 611577 |
| RefSeq mRNA | NM_001080424.1 |
| RefSeq Protein | NP_001073893.1 |
| Disease associations | Cancer: Hodgkin's Lymphoma; PMID: 21242977 Cancer: Prostate cancer; PMID: 17923864 |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B