Lysine-specific demethylase NO66
NO66 belongs to MINA53/NO66 family that contains the JmJC domain. It demethylates H3K4me3 and H3K36me3. This activity is important for the transcriptional regulation of osteoblast-specific promoters (PMID: 19927124).
| UniprotKB Accession | Q9H6W3 |
|---|---|
| Alternative Name(s) | Nucleolar protein 66 (hsNO66) |
| Eraser for PTM/s | H3K4me3, H3K36me3 |
| EC number | 1.14.11.27 |
| No. of coding genes | Lysine-specific demethylase NO66 is coded by following 1 non-allelic gene/s |
| Gene name | chromosome 14 open reading frame 169 |
| Gene symbol | C14orf169 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | FLJ21802, NO66 |
| GeneID | 79697 |
| Chromosomal location | 14q24.2 |
| HGNC | 20968 |
| Unigene | Hs.509916 |
| MIM | 611919 |
| RefSeq mRNA | NM_024644.2 |
| RefSeq Protein | NP_078920.2 |
| Disease associations | No disease associations known for Lysine-specific demethylase NO66 |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B