Bifunctional protein NCOAT

Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a bifunctional enzyme consisting of glycoside hydrolase and histone acetyltransferase activity (PMID: 16356930). NCOAT has been shown to acetylate free as well as reconstituted nucleosomal histones and hence may mediate activation of gene transcription (PMID: 15485860).

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Bifunctional protein NCOAT infosheet
UniprotKB AccessionO60502
Alternative Name(s)Meningioma-expressed antigen 5, Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
Writer for PTM/s H4K8ac, H3K14ac
EC number,
No. of coding genesBifunctional protein NCOAT is coded by following 1 non-allelic gene/s
Gene namemeningioma expressed antigen 5 (hyaluronidase)
Gene symbolMGEA5
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location10q24.1-q2
RefSeq mRNANM_001142434.1NM_012215.3
RefSeq ProteinNP_001135906.1NP_036347.1
Disease associationsNo disease associations known for Bifunctional protein NCOAT

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1