General transcription factor 3C polypeptide 4
TFIIC90 has been shown to bind chromatin and possess an intrinsic histone acetyltransferase activity. It has the potential to acetylate free as well as nucleosomal histones and further relieve chromatin mediated transcriptional repression as shown in the case of tRNA genes (PMID: 9891093). TFIIC90 has a substrate specificity for lysine 14 of histone H3 (PMID: 8980232, PMID: 10523658).
| UniprotKB Accession | Q9UKN8 |
|---|---|
| Alternative Name(s) | TF3C-delta, Transcription factor IIIC 90 kDa subunit (TFIIIC 90 kDa subunit, TFIIIC90), Transcription factor IIIC subunit delta |
| Writer for PTM/s | H3K14ac |
| EC number | 2.3.1.48 |
| No. of coding genes | General transcription factor 3C polypeptide 4 is coded by following 1 non-allelic gene/s |
| Gene name | general transcription factor IIIC, polypeptide 4, 90kDa |
| Gene symbol | GTF3C4 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | TFIIIC90, KAT12 |
| GeneID | 9329 |
| Chromosomal location | 9q34.3 |
| HGNC | 4667 |
| Unigene | Hs.656646 |
| MIM | 604892 |
| RefSeq mRNA | NM_012204.2 |
| RefSeq Protein | NP_036336.2 |
| Disease associations | No disease associations known for General transcription factor 3C polypeptide 4 |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1