Histone acetyltransferase MYST2
Hbo1 belongs to the MYST class of acetyltransferases. It interacts with the origin recognition complex (ORC) and this interaction is evolutionarily conserved. Hence this ORC-mediated histone H4 acetylation is supposed to play a role in DNA replication via licensing of replication origins and gene regulation. It is responsible for the bulk acetylation of H4 (PMID: 10438470, PMID: 20129055). Hbo1 protein level is shown to be upregulated in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder (PMID: 19393168).
| UniprotKB Accession | O95251 |
|---|---|
| Alternative Name(s) | Histone acetyltransferase binding to ORC1, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 |
| Writer for PTM/s | H4K5ac, H4K8ac, H4K12ac |
| EC number | 2.3.1.48 |
| No. of coding genes | Histone acetyltransferase MYST2 is coded by following 1 non-allelic gene/s |
| Gene name | MYST histone acetyltransferase 2 |
| Gene symbol | MYST2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | HBOA, HBO1, KAT7 |
| GeneID | 11143 |
| Chromosomal location | 17q21.32 |
| HGNC | 17016 |
| Unigene | Hs.21907 |
| MIM | 609880 |
| RefSeq mRNA | NM_007067.4 |
| RefSeq Protein | NP_008998.1 |
| Disease associations | Cancer: Breast cancer; PMID: 21040551 Cancer: Multiple; PMID: 19393168 |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1