Probable histone acetyltransferase MYST1
MYST1 is also known as MOF. H4K16 acetylation mediated by MYST1 is crucial for DNA damage response and DNA double strand break responses (PMID: 20479123) (PMID: 17694080). mRNA and protein levels of MYST1 are found to be significantly reduced in primary breast carcinomas and medulloblastomas (PMID: 18058815). Downregultion of MOF causes significant decrease in H4K16 acetylation resulting in reduced transcription of cetain genes and cell cycle arrest in G2/M phase (PMID: 16227571).
| UniprotKB Accession | Q9H7Z6 | |
|---|---|---|
| Alternative Name(s) | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 (hMOF) | |
| Writer for PTM/s | H4K16ac | |
| EC number | 2.3.1.48 | |
| No. of coding genes | Probable histone acetyltransferase MYST1 is coded by following 1 non-allelic gene/s | |
| Gene name | MYST histone acetyltransferase 1 | |
| Gene symbol | MYST1 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | MOF, FLJ14040, hMOF, KAT8 | |
| GeneID | 84148 | |
| Chromosomal location | 16p11.1 | |
| HGNC | 17933 | |
| Unigene | Hs.533803 | |
| MIM | 609912 | |
| RefSeq mRNA | NM_032188.2 | NM_182958.2 |
| RefSeq Protein | NP_115564.2 | NP_892003.2 |
| Disease associations | No disease associations known for Probable histone acetyltransferase MYST1 | |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1