Histone acetyltransferase type B catalytic subunit
Also known as Hat1. It is present subcellularly and acetylates the soluble histone H4/H2A and not the nucleosomal fraction. Acetylation by Hat1 might be involved in the silencing of cells that were earlier transcriptionally active (PMID: 9427644). Hat1 is shown to be upregulated distinctly both at transcript and protein level in human colorectal cancer tissues (PMID: 16158056, PMID: 17694075).
| UniprotKB Accession | O14929 |
|---|---|
| Alternative Name(s) | |
| Writer for PTM/s | H4K5ac, H4K12ac, H2AK5ac |
| EC number | 2.3.1.48 |
| No. of coding genes | Histone acetyltransferase type B catalytic subunit is coded by following 1 non-allelic gene/s |
| Gene name | histone acetyltransferase 1 |
| Gene symbol | HAT1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KAT1 |
| GeneID | 8520 |
| Chromosomal location | 2q31.2-q33 |
| HGNC | 4821 |
| Unigene | Hs.632532 |
| MIM | 603053 |
| RefSeq mRNA | NM_003642.3 |
| RefSeq Protein | NP_003633.1 |
| Disease associations | Cancer: Colorectal cancer; PMID: 16158056 |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1