Histone acetyltransferase KAT2A
KAT2A also known as GCN5 (general control nonderepressible 5) is a human histone acetyltransferase and its activity is conserved from yeasts to humans. It is important for transcriptional activation (PMID: 8972232). Gcn5 is also responsible for the acetylation of histone H3 at the gamma-H2A.X harbouring nucleosomes at the site of DNA damage, thus establishing a cross-talk between the two histone modifications (PMID: 20224553).
| UniprotKB Accession | Q92830 |
|---|---|
| Alternative Name(s) | General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5 (HsGCN5), Lysine acetyltransferase 2A, STAF97 |
| Writer for PTM/s | H3K9ac, H3K14ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac, H4K91ac |
| EC number | 2.3.1.48 |
| No. of coding genes | Histone acetyltransferase KAT2A is coded by following 1 non-allelic gene/s |
| Gene name | K(lysine) acetyltransferase 2A |
| Gene symbol | KAT2A |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | GCN5L2 |
| Aliases | GCN5, PCAF-b |
| GeneID | 2648 |
| Chromosomal location | 17q12-q21 |
| HGNC | 4201 |
| Unigene | Hs.463045 |
| MIM | 602301 |
| RefSeq mRNA | NM_021078.2 |
| RefSeq Protein | NP_066564.2 |
| Disease associations | No disease associations known for Histone acetyltransferase KAT2A |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1