Histone acetyltransferase p300
p300 along with CBP exhibit histone acetyltransferase activity (PMID: 8945521). It has been shown that the PHD domain of p300 is dispensable for acetyltransferase activity (PMID: 11691934). A viral oncoprotein E1A is shown to inhibit the histone acetyltrasferase activity of p300/CBP (PMID: 10025405). Acetylation of different lysine residues of histone H3 and H4 by CBP/p300 at the site of double stranded DNA breaks generated during IR radiation have been shown to recruite SWI/SNF chromatin remodellers for DNA repair. Hence, inhibition of CBP activity can help is sensitising cancer cells to radiotherapy or chemotherapy (PMID: 21217779).
| UniprotKB Accession | Q09472 |
|---|---|
| Alternative Name(s) | E1A-associated protein p300 |
| Writer for PTM/s | H3K27ac, H3K56ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac, H3K18ac |
| EC number | 2.3.1.48 |
| No. of coding genes | Histone acetyltransferase p300 is coded by following 1 non-allelic gene/s |
| Gene name | E1A binding protein p300 |
| Gene symbol | EP300 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | p300, KAT3B |
| GeneID | 2033 |
| Chromosomal location | 22q13.2 |
| HGNC | 3373 |
| Unigene | Hs.517517 |
| MIM | 602700 |
| RefSeq mRNA | NM_001429.3 |
| RefSeq Protein | NP_001420.2 |
| Disease associations | Cancer: Leukemia; PMID: 10700188 Cancer: Breast cancer; PMID: 10700188 Cancer: Pancreatic carcinoma; PMID: 10700188 Cancer: Colorectal cancer; PMID: 10700188 Cancer: Colorectal cancer; PMID: 8622873 Cancer: Gastric cancer; PMID: 8622873 Cancer: Cervical cancer; PMID: 11181085 Developmental disorder: RTS (Rubinstein- Taybi syndrome); PMID: 15706485 |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1