Histone-lysine N-methyltransferase SETDB1
SETDB1 is part of a multimeric complex which comprises of various methyltransferases like Suv39h1, G9a and GLP (PMID: 20129054). It is known to form a complex consisting of HP1alpha-CAF1-SETDB1 which is involved in the methylation of H3K9 in the pericentric heterochromatin in DNA replication (PMID: 19498464) (PMID: 15327775).
| UniprotKB Accession | Q15047 | |
|---|---|---|
| Alternative Name(s) | ERG-associated protein with SET domain (ESET), SET domain bifurcated 1 | |
| Writer for PTM/s | H3K9me3 | |
| EC number | 2.1.1.43 | |
| No. of coding genes | Histone-lysine N-methyltransferase SETDB1 is coded by following 1 non-allelic gene/s | |
| Gene name | SET domain, bifurcated 1 | |
| Gene symbol | SETDB1 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | KG1T, KIAA0067, ESET, KMT1E | |
| GeneID | 9869 | |
| Chromosomal location | 1q21 | |
| HGNC | 10761 | |
| Unigene | Hs.643565 | |
| MIM | 604396 | |
| RefSeq mRNA | NM_001145415.1 | NM_012432.3 |
| RefSeq Protein | NP_001138887.1 | NP_036564.3 |
| Disease associations | Developmental defect: Embryonic lethality; PMID: 14993285 | |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3