Histone-lysine N-methyltransferase PRDM9
Trimethylation of H3K4 is mediated by meiosis specific PRDM9 histone methyltransferase. This binding of PRDM9 to certain human motifs has been linked to major human meiotic recombination hotspots (PMID: 20044539, PMID: 20877321).
| UniprotKB Accession | Q9NQV7 |
|---|---|
| Alternative Name(s) | PR domain zinc finger protein 9, PR domain-containing protein 9 |
| Writer for PTM/s | H3K4me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase PRDM9 is coded by following 1 non-allelic gene/s |
| Gene name | PR domain containing 9 |
| Gene symbol | PRDM9 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | PFM6, ZNF899 |
| GeneID | 56979 |
| Chromosomal location | 5p14.2 |
| HGNC | 13994 |
| Unigene | Hs.283096 |
| MIM | 609760 |
| RefSeq mRNA | NM_020227.2 |
| RefSeq Protein | NP_064612.2 |
| Disease associations | No disease associations known for Histone-lysine N-methyltransferase PRDM9 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3