Histone-lysine N-methyltransferase SETD7
SET9 is a histone methyltransferase containing a SET domain and it specifically catalyses monomethylation of H3K4 (PMID: 11850410, PMID: 12540855). SET7 is known to regulate DNA methyltransferase (DNMT1) by methylating it (PMID: 19282482). SET9 is reported to regulate the expression of p53-target genes via methylation of p53 (PMID: 15525938). SET9 is shown to influence DNA damage induced apoptosis by regulating E2F1 via methylation in p53 deficient tumour cell lines (PMID: 20603083). SET9 also regulates NF-kB by post translational methylation of targets like p65 and RelA (PMID: 19864627, PMID: 19262565).
| UniprotKB Accession | Q8WTS6 |
|---|---|
| Alternative Name(s) | SET domain-containing protein 7 |
| Writer for PTM/s | H3K4me1 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase SETD7 is coded by following 1 non-allelic gene/s |
| Gene name | SET domain containing (lysine methyltransferase) 7 |
| Gene symbol | SETD7 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA1717, SET7, SET7/9, Set9, KMT7 |
| GeneID | 80854 |
| Chromosomal location | 4q31.1 |
| HGNC | 30412 |
| Unigene | Hs.480792 |
| MIM | 606594 |
| RefSeq mRNA | NM_030648.2 |
| RefSeq Protein | NP_085151.1 |
| Disease associations | Inflammatory disorder: ; PMID: 18650421 Metabolic disorder: Diabetes; PMID: 18650421 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3