N-lysine methyltransferase SMYD2
SMYD2 catalyses dimethylation of histone H3 at lysine 36 position. It has a SET domain and an MYND domain that forms a unique domain architecture. It has important implications in cell proliferation and cardiogenesis (PMID: 16805913).
| UniprotKB Accession | Q9NRG4 |
|---|---|
| Alternative Name(s) | HSKM-B, Histone methyltransferase SMYD2, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2 |
| Writer for PTM/s | H3K36me2 |
| EC number | 2.1.1.-, 2.1.1.43 |
| No. of coding genes | N-lysine methyltransferase SMYD2 is coded by following 1 non-allelic gene/s |
| Gene name | SET and MYND domain containing 2 |
| Gene symbol | SMYD2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | HSKM-B, ZMYND14, KMT3C |
| GeneID | 56950 |
| Chromosomal location | 1q32.3 |
| HGNC | 20982 |
| Unigene | Hs.66170 |
| MIM | 610663 |
| RefSeq mRNA | |
| RefSeq Protein | |
| Disease associations | Cancer: Esophageal squamous cell carcinoma; PMID: 19423649 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3