Probable histone-lysine N-methyltransferase ASH1L
Ash1 is a SET domain containing protein that exclusively mono- and di- methylates histone H3 Lysine 36 (PMID: 17544230). Ash1 is found to be associated with transcriptionally active genes (PMID: 17923682).
| UniprotKB Accession | Q9NR48 |
|---|---|
| Alternative Name(s) | ASH1-like protein (huASH1), Absent small and homeotic disks protein 1 homolog, Lysine N-methyltransferase 2H |
| Writer for PTM/s | H3K36me1, H3K36me2 |
| EC number | 2.1.1.43 |
| No. of coding genes | Probable histone-lysine N-methyltransferase ASH1L is coded by following 1 non-allelic gene/s |
| Gene name | ash1 (absent, small, or homeotic)-like (Drosophila) |
| Gene symbol | ASH1L |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | huASH1, ASH1, ASH1L1, KMT2H |
| GeneID | 55870 |
| Chromosomal location | 1q22 |
| HGNC | 19088 |
| Unigene | Hs.491060 |
| MIM | 607999 |
| RefSeq mRNA | NM_018489.2 |
| RefSeq Protein | NP_060959.2 |
| Disease associations | No disease associations known for Probable histone-lysine N-methyltransferase ASH1L |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3