Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
G9a catalyse the mono and dimethylation of H3K9 and H3K27 with high specificity which is important for chromatin organisation (PMID: 11316813). G9a is reported to mediate transcriptional repression via interaction with CDP/cut complex (PMID: 15269344). G9a self-methylates and creates a binding site for the Heterochromatin protein (HP1) (PMID: 17707231). It promotes metastasis of lung cancers by repression of cell adhesion molecules (PMID: 20940408). G9a is also reported to influence T helper cell differentiation via complex regulatory mechanisms demonstrating its role in immune system (PMID: 20421388). G9a is shown to methylate histone H1.2 in a variant specific manner (PMID: 20334638). It is part of a large multimeric complex comprising of Suv39h1, GLP1 and SETDB1 (PMID: 20129054).
| UniprotKB Accession | Q96KQ7 | |
|---|---|---|
| Alternative Name(s) | ||
| Writer for PTM/s | H3K9me1, H3K9me2, H3K27me1, H1K186me1, H1K25me1 | |
| EC number | ||
| No. of coding genes | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 is coded by following 1 non-allelic gene/s | |
| Gene name | euchromatic histone-lysine N-methyltransferase 2 | |
| Gene symbol | EHMT2 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | C6orf30, BAT8 | |
| Aliases | G9A, Em:AF134726.3, NG36/G9a, KMT1C | |
| GeneID | 10919 | |
| Chromosomal location | 6p21.3 | |
| HGNC | 14129 | |
| Unigene | Hs.709218 | |
| MIM | 604599 | |
| RefSeq mRNA | NM_006709.3 | NM_025256.5 |
| RefSeq Protein | NP_006700.3 | NP_079532.5 |
| Disease associations | Developmental defect: Embryonic lethality; PMID: 12130538 Cancer: Colon cancer; PMID: 19843671 Cancer: Bladder carcinomas; PMID: 21847359 | |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3